STAGE OF DEVELOPMENT
& RESULTS OF INTELLECTUAL ACTIVITY STATUS
Therapy and prophylaxis of cognitive disorders associated with cholinergic system dysfunction.
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The Shemyakin & Ovchinnikov Institute of bioorganic chemistry (IBCh) of the Russian Academy of Sciences is one of the largest Russian scientific organizations. The Institute is a leader in fundamental and innovative researches on the fields of molecular, structural and cell biology, bioorganic chemistry, biophysics, bioengineering, cell technologies, “in vivo” molecular based bioimaging, genome editing, bioinformatics etc. This multidisciplinary structure allows large-scale research at the interface of sciences, where the most interesting scientific discoveries are born today.
The hallmark of the IBCh RAS is the concentration of efforts and resources on solving the most urgent and complicated problems on the field of life sciences. Talented young people and leading specialists, including Russian and foreign science leaders, Nobel Prize laureates and members of the international advisory council of the Institute are involved in.
Head of the Laboratory for Bioengineering of Neuromodulators and Neuroreceptors, IBCh RAS
2020/ Water-soluble variant of human Lynx1 positively modulates synaptic plasticity and ameliorates cognitive impairment associated with α7-nAChR dysfunction.
8. Z.O. Shenkarev, M.A. Shulepko, M.L. Bychkov, D.S. Kulbatskii1, O.V. Shlepova, N.A. Vasilyeva, A.A. Andreev-Andrievsky, A.S. Popova, E.A. Lagereva, E.V. Loktyushov, S.G. Koshelev, M.S. Thomsen, D.A. Dolgikh, S.A. Kozlov, P.M. Balaban, M.P. Kirpichnikov, E.N. Lyukmanova.
Journal of neurochemistry. Volume155, Issue1. Pages 45-61
Lynx1 prevents long-term potentiation blockade and reduction of neuromodulator expression caused by Aβ1-42 and JNK activation
Bychkov ML, Vasilyeva NA, Shulepko MA, Balaban PM, Kirpichnikov MP, Lyukmanova EN.
2018/ Acta Naturae. 2018;3(38):57-61. (рус.61-66)
Three-Finger Proteins from the Ly6/uPAR Family: Functional Diversity within One Structural Motif
Biochemistry (Mosc). 2017 82(13):1702-1715. doi: 10.1134/S0006297917130090. Review.
2016/ Neurobiology of Aging, Volume 46, 2016, Pages 13-21
Expression of the Ly-6 family proteins Lynx1 and Ly6H in the rat brain is compartmentalized, cell-type specific, and developmentally regulated
(2014) Brain Struct Funct. 219(6):1923-1934.
Ws-LYNX1 Residues Important for Interaction with Muscle-Type and/or Neuronal Nicotinic Receptors
(2013) J Biol Chem. 288(22):15888-15899.
Бактериальная продукция водорастворимого домена lynx1, - эндогенного нейромодулятора никотиновых рецепторов человека
Биоорг. хим. (2011), 37(5): 609-615. (543-549)
NMR structure and action on nicotinic acetylcholine receptors of water-soluble domain of human lynx1
J.Biol.Chem.(2011), 286: 10618-10627.
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