STAGE OF DEVELOPMENT
& RESULTS OF INTELLECTUAL ACTIVITY STATUS
Can be used as API for neurodegenerative and cerebrovascular diseases therapy drugs creation, including treatment of Alzheimer's disease and ischemic stroke.
Description: Dry powder/liofilizate for intranasal dosage forms preparation.
Storage: +4 C.
- Intellectual and mental disorders associated with brain lesions of various genesis
- Consequences of craniocerebral injuries, neurosurgical interventions, stroke, chronic cerebral circulatory disorders
- As a preventive agent to prevent stroke and neurological disorders
The Shemyakin & Ovchinnikov Institute of bioorganic chemistry (IBCh) of the Russian Academy of Sciences is one of the largest Russian scientific organizations. The Institute is a leader in fundamental and innovative researches on the fields of molecular, structural and cell biology, bioorganic chemistry, biophysics, bioengineering, cell technologies, “in vivo” molecular based bioimaging, genome editing, bioinformatics etc. This multidisciplinary structure allows large-scale research at the interface of sciences, where the most interesting scientific discoveries are born today.
The hallmark of the IBCh RAS is the concentration of efforts and resources on solving the most urgent and complicated problems on the field of life sciences. Talented young people and leading specialists, including Russian and foreign science leaders, Nobel Prize laureates and members of the international advisory council of the Institute are involved in.
Российский ученый. Ведущий специалист в области химии белков и пептидов.
Награды и премии: Орден Дружбы Народов, Государственная премия в области науки и техники, Премии РАН имени Ю.А.Овчинникова и именная золотая медаль.
Comparative study of the neuroprotective and nootropic activities of the carboxylate and amide forms of the HLDF-6 peptide in animal models of Alzheimer's disease
The Qualitative Analysis of the Amide Derivative of HLDF-6 Peptide and Its Metabolites with the Use of Tritium- and Deuterium-Labeled Derivatives
A Zolotarev, A K Dadayan, N V Kost, M E Voevodina, O Y Sokolov, V S Kozik, S I Shram, V N Azev, E V Bocharov, A P Bogachouk, V M Lipkin, N F Myasoedov
Influence of Subchronic Administration of the HLDF-6 Peptide on an Efficacy of the Exploratory Behavior of Inbred Mice of the Balb/c and C57Bl/6 Strains
Georgy I Kovalev, E. V. Vasil’eva, Ramiz M Salimov,Yu. A. Zolotarev, A. K. Dadayan, A. P. Bogachouk, Valery Lipkin
Specific activity of the amide form of HLDF-6 peptide: study in a transgenic model of Alzheimer's disease
Comparative study of carboxylate and amide forms of HLDF-6 peptide: Neuroprotective and nootropic effects in animal models of ischemic stroke
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